We are a research group at the UNSW RNA Institute and School of Biotechnology and Biomolecular Sciences in Sydney, Australia. We study how RNA controls gene expression and changes using genomics and bionformatics.

We are a research group at the UNSW RNA Institute and School of Biotechnology and Biomolecular Sciences in Sydney, Australia. We study how RNA controls gene expression and changes using genomics and bionformatics.

The genomic revolution unveiled a plethora of novel regulatory molecules, in particular non-coding RNAs - RNA molecules that presumably do not encode proteins. Even though some RNAs have long been known to have gene regulatory and catalytic capabilities, only in recent years has the sheer scale of regulatory capabilities of non-coding RNAs been truly envisioned.
In the RegRNALab, we leverage bioinformatic and genomic data analysis to understand how gene regulatory mechanisms change through time, while maintaining the intricate development and diversity of cells we find in multicellular plants and animals.
We are particularly interested in understanding the evolutionary dynamics of non coding RNA molecules and how they coordinate major epigenetic rearrangements. For this, we study a number of biological models that span different evolutionary scales, including humans, plants and animals.
We aim to identify and characterise gene control mechanisms to unveil new medical and biotechnological applications of transitory gene control using RNA. We are actively developing RNA-based technology for plants.
We are currently comparing the evolution of lncRNAs in syntenic regions in plants to measure how quickly they are lost gain across plant evolution. We also aim to understand what fraction of lncRNAs are under splicing, positional and structural selection in this kingdom.
One of the greatest limiting factors in the identification of lncRNA function is the lack of functional information at the modular level that could potentially be extrapolated to other lncRNAs. We are working in the identification of “structural domains” in lncRNAs that allow us to infer the function of such molecules de novo using bioinformatic methods for their identification join with experimental methods for functional validation.
We are actively developing biocontrol strategies based on RNA technology using AI to expedite molecule design and testing.

I’m a bioinformatician and genomic data scientist studying the evolution of gene regulatory mechanisms underlying the phenotypic diversity and cell differentiation in multicellular eukaryotes. I’m particularly interested in the regulatory roles of non-coding RNAs in these processes.
I have a BSc in Genomic Sciences from the National Autonomous University of Mexico (LCG-UNAM) and a PhD in Bioinformatics from the Institute for Molecular Biosciences (IMB) at the University of Queensland, Australia. I did my postdoc at the School of Biological Sciences, also at UQ.
In addition to my academic roles, I actively participate in initiatives that link scientists and the general public (such as Mas Ciencia por Mexico, Clubes de Ciencia Mexico), programs to introduce researchers to computing (Software/Data Carpentry, Red Mexicana de Bioinformatica) as well as mentoring programs (Ekpapalek and Mujeres en STEM: Futuras Líderes, from the US-Mexico Foundation).
I’ve been honoured with one of five recipients of the L’Oreal-UNESCO research fellowship For Women in Science - Mexico chapter - in 2016 and one of 15 worldwide L’Oreal-UNESCO For Women In Science International Rising Talents fellowship in 2018. I was also named one of 100 most powerful women in Mexico by Forbes Mexico magazine in 2018. I’m an ARC Future Fellow since January 2025.
When not behind a computer, you can find me hiking, scuba diving or spending time with my F1.
She holds a BSc in Biology from the Faculty of Science, UNAM, Mexico, and an MSc in Integrative Biology from Cinvestav, Mexico. She recently submitted her PhD thesis from the University of New South Wales. She is interested in Evolution and RNA Biology; her research expands from microRNA evolution in Metazoa and circular RNAs in Primates to mRNA isoform evolution in Vertebrates. She has recently joined the Regulatory RNA lab to study the evolution of lncRNAs in Brassicaceae. In her free time, she enjoys training Muay Thai and BJJ and spending time with her cat.

Xingyu holds a BSc in Plant Protection from the Faculty of Plant Health & Medicine, QAU, China, and an MSc in Plant Sciences from the Faculty of Mathematics and Natural Sciences, University of Bonn, Germany. She later spent a year as a research assistant in the School of Life Sciences, CUHK, Hong Kong SAR. Her main interest is Plant RNA Biology, she joined the Regulatory RNA lab in 2024 to dive deep into the world of RNA-protein interactions in plants. While she’s currently making her mark in the wet lab, she’s also an enthusiastic beginner in bioinformatics, eager to expand her skills!

She holds a Bachelor of Engineering and a master’s degree in biotechnology from Institut Teknologi Bandung, Indonesia, where she focused on post-harvest handling and technology of crops. Before commencing her PhD at UNSW, she worked as a business consultant, with a growing interest in integrating plant science and technology into industry applications. Her current research focuses on analysing RNA structure and its interaction with proteins, particularly in the context of gene regulation in plants. She is also expanding her budding skills in bioinformatics. Outside of research, she enjoys hiking and crocheting.

Bryan is an honours student at UNSW, completing his undergraduate degree in BAdvSc with a major in Molecular and Cellular Biology. His main interest is in cancer research with his honours project focusing on mRNA vaccines for breast cancer. He aims to evaluate the immune response in mouse breast cancer tumour cells treated with mRNA nanoparticles. He joined the Regulatory RNA lab to further develop his practical and bioinformatics skills while gaining valuable research experience.

Byron is a genetics honours student currently studying RNA-RBP relationships in plants. More specifically, he is attempting to uncover the binding partners of a key RBP in Arabidopsis thaliana, with the hopes of expanding this research to more plants. His goal is to gain a better understanding of the properties that allow plants to survive environmental stress with potential agricultural biotechnology applications, while gaining critical laboratory and research skills along the way. In his spare time, Byron is a big Football fan and enjoys playing Pokémon games.

Winston is a biotechnology honours student from Kuala Lumpur, Malaysia currently working on developing RNA control strategies to protect native wildlife. His overall goal is to learn laboratory and technical skills which will help him leave a positive lasting impact on people’s livelihood and quality of life. Outside of the lab, he enjoys learning about history and geography and plays strategy games.

Billi completed a Bachelor of Biotechnology degree (1st Class Honours) at The University of Wollongong in 1997. She worked as a Research Assistant at the Royal North Shore Hospital and at The Children’s Hospital at Westmead. She completed her PhD in 2004 at The University of Sydney and continued as a Post-doc for the next decade working on genetic neuromuscular disorders. In 2019, Billi joined UNSW as a lab manager and has continued in this role with the Regulatory RNA lab in February 2025.

Molecular biologist, university lecturer, and doctoral student with experience in molecular diagnostics, epidemiology, biotechnology, and applied health research. Currently Head of the Molecular Biology Department at Amadita Laboratorio Clínico and Adjunct Professor at Universidad Iberoamericana (UNIBE), teaching epidemiology, biostatistics, and research methodology. Her work focuses on infectious diseases, molecular diagnostic techniques, laboratory quality processes, and accessible diagnostic strategies for low-resource settings. She holds a Master’s degree in Advanced Biotechnology from Universidade da Coruña and is currently pursuing a doctoral degree in Health and Behavioral Sciences Research at UNIBE. Her research interests include molecular diagnostics for infectious and arboviral diseases, applied molecular biology, and rapid diagnostic tools for tropical regions, particularly in the Caribbean
Sergio Nigenda-Morales, Postdoctoral Researcher, Cinvestav - now Assistant Professor, California State University San Marcos, USA
Victor Flores Lopez, Postdoctoral Researcher, Cinvestav - now Postdoctoral Researcher, University of Cambridge, UK
Jose Cetz-Chel, Postdoctoral Researcher, Cinvestav - now Postdoctoral Researcher, Universidad de Guadalajara, Mexico
Francisco Javier Perez de los Santos - now Postdoctoral Researcher, University of Colorado Anschutz Medical Campus, USA
Irving García Lopez - PhD & MSc Plant Biotechnology, Cinvestav - now Postdoctoral Researcher, Cinvestav, Mexico
Edmundo Dominguez Rosas - PhD Science Program, CIAD
Gabriel Martinez Medina - MSc Plant Biotechnology, Cinvestav - now PhD student, Institut Botanic Barcelona, Spain
Adrián Díaz Chávez - MSc Integrative Biology, Cinvestav
Evelia Coss Navarrete - PhD Plant Biotechnology, Cinvestav - now Postdoctoral Research, LIIGH, UNAM, Mexico
Jaime Pérez Patiño - BSc & MSc Plant Biotechnology, Cinvestav
Pablo Rosiles Loeza - MSc Plant Biotechnology, Cinvestav - now AI & Data Analytics Specialist, DataCloud Technologies and Consulting, Mexico
Judith Ballesteros Villascan - MSc Integrative Biology, Cinvestav - now PhD Student, Max Planck Institute for Evolutionary Anthropology, Germany
América Ramírez Colmenero - MSc Integrative Biology, Cinvestav - now PhD Student, Max Perutz Labs, Vienna
Stephanie Mata Bonilla - MSc Plant Biotechnology, Cinvestav
José Antonio Corona Gómez - Postdoctoral Researcher & PhD Plant Biotechnology, Cinvestav - now Postdoctoral Researcher, Cinvestav, Mexico
Jordan Pérez Medina - MSc Plant Biotechnology, Cinvestav
Emiliano Sotelo Fonseca - BSc & MSc Plant Biotechnology, Cinvestav - now PhD Student, Center for Genomic Regulation, Spain
Alexander Ramos Díaz - MSc Integrative Biology, Cinvestav
Francisco Falcón Chávez - MSc Integrative Biology, Cinvestav - now PhD Student, Institute of Molecular Biotechnology, Vienna
Federico Gaiti - PhD, School of Biological Sciences, The University of Queensland - now Assistant Professor, Princess Margaret Cancer Research Centre, Canada
Andrew Calcino - PhD, School of Biological Sciences, The University of Queensland - now Lecturer, James Cook University, Australia
Rafael Rincon Ramirez, Internship, Cinvestav - Now Senior AI Engineer, EAS Consulting MX, Mexico
Lorena Gomez Godinez, Internship, Cinvestav - now Research Group Leader at INIFAP, Mexico
Christopher Klapproth, Internship, Cinvestav
Leyda Cortez Maldonado, Internship, Cinvestav
Jose Luis Garcia Corona, Internship, Cinvestav
Ramon Valdez Melchor, Internship, Cinvestav
Dharam Arora, Undergrad Internship, Computer Science, UNSW
Rotation students not listed
Want to read our latest research? Check out our preprints on bioRxiv
Ana Laura Hernandez-Ledesma AL, Coss-Navarrete EL, Salazar-Magana S, Ramirez-Espinosa D, Tinajero-Nieto L, Torres-Valdez E, Pena-Ayala A, Felix-Rodriguez G, Frontana-Vazquez G, Garcia Sotelo JS, Thomas-Chollier M, Trynka G, Rosetti F, Fernandez-Valverde SL, Gutierrez-Arcelus M, Alpizar-Rodriguez D, Medina-Rivera A. Frontiers in Immunology - Accepted
Tenorio M, Cruz-Ruiz S, Encarnacion-Guevara S, Hernandez M, Corona-Gomez JA, Sheccid-Santiago F, Serwatowska J, Lopez-Perdomo S, Flores-Aguirre CD, Arenas-Moreno DM, Ossiboff RJ, Mendez-de-la-Cruz F, Fernandez-Valverde SL, Zurita M, Oktaba K, Cortez D. Science | Journal
Garcia-Lopez IJ, Velez-Ramirez AI, Gillmor CS, Fernandez-Valverde SL.
BMC Genomics
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Domínguez-Rosas E, Hernández-Oñate MÁ, Fernandez-Valverde SL, Tiznado-Hernández ME. Frontiers in Plant Science | PDF | Journal
Sohail M, Palma-Martinez MJ, Chong AY, Quinto-Cortes CD, Ragsdale A, Medina-Munoz SG, Barberena- Jonas C, Delgado-Sanchez G, Cruz-Hervert LP, Ferreyra-Reyes L, Ferreira-Guerrero E, Mongua-Rodriguez N, Jimenez-Kaufmann A, Moreno-Macias H, Aguilar-Salinas CA, Auckland K, Cortes A, Acuna-Alonzo V, Ioannidis AG, Gignoux CR, Wojcik GL, Fernandez-Valverde SL, Hill AVS, Tusie-Luna MT, Mentzer AJ, Novembre J, Garcia-Garcia L, Moreno-Estrada Nature | ReadCube | Journal | bioRxiv
Tenorio M, Serwatowska J, Fernandez-Valverde SL, Oktaba K, Cortez D. BMC Genomics | PDF | Journal
Fernandez-Valverde SL Nature Reviews Genetics | PDF | Journal
Perez-de los Santos FJ, Sotelo-Fonseca JE, Ramirez-Colmenero A, Nutzmann H-W, Fernandez-Valverde SL*
Oktaba K
Book chapter. Plant Comparative Genomics. Methods in Molecular Biology
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* Corresponding author
Corona-Gomez JA, Coss-Navarrete EL, Garcia-Lopez IJ, Klapproth C, Perez-Patino JA, Fernandez-Valverde
SL*
Scientific Reports
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* Corresponding author
VanBuren R, Rougon-Cardoso A, Amezquita EJ, Coss-Navarrete E, Espinosa-Jaime A, Gonzalez-Iturbe O, Luckie-Duque A, Mendoza-Galindo E, Pardo J, Rodriguez-Guerrero G, Rosiles-Loeza P, Vasquez-Cruz M, Fernandez-Valverde SL, Hernandez-Hernandez T, Palande S, Chitwood DH The Plant Cell - Teaching tools in plant biology | PDF | Journal
Jimenez-Kaufmann A, Chong AY, Cortes A, Fernandez-Valverde SL, Ferreyra-Reyes L, Cruz-Hervert P, Quinto-Cortes CD, Sohail M, Palma-Martinez MJ, Delgado-Sanchez G, Mentzer AJ, Hill AV, Moreno- Macias H, Huerta-Chagoya A, Aguilar-Salinas CA, Torres M, Kim HL, Kalsi N, Schuster SC, Tusie-Luna T, Ortega-Del Vecchyo D, Garcia-Garcia L and Moreno-Estrada A Frontiers in Genetics | PDF | Journal
Ozment E, Tamvacakis AN, Zhou J, Rosiles-Loeza PY, Escobar-Hernandez EE, Fernandez-Valverde SL, Nakanishi N eLife | PDF | Journal | bioRxiv
Moore B, Carvajal-Lopez P, Chauke PA, Cristancho M, Domiguez del Angel V, Fernandez-Valverde SL, Ghouila A, Gopalasingam P, Guerfali FZ, Matimba A, Morgan SL, Oliveira G, Ras V, Reyes A, De Las Rivas J, Mulder N PloS Computational Biology | PDF | Journal
Ramirez Colmenero A, Oktaba K and Fernandez-Valverde SL*. Frontiers in Genetics | PDF | Journal * Corresponding author
Fernandez-Valverde SL Nature Reviews Molecular Cell Biology | PDF | Journal
Corona-Gomez JA, Garcia-Lopez IJ, Stadler PF* and Fernandez-Valverde SL*.
RNA
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* Corresponding author
Nutzmann H-W*, Ramirez Colmenero A, Sotelo JE, Wegel E, di Stefano M, Wingett S, Fraser P, Hurst L, Fernandez-Valverde SL and Osbourn A .
Proceedings of the National Academy of Science
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* Corresponding author
Sogabe S*, Hatleberg WL*, Kocot KM, Say TE, Stoupin D, Roper KE, Fernandez-Valverde SL, Degnan SM and Degnan BM Nature | ReadCube | Journal | bioRxiv * Equal contribution
Gomez-Godinez LJ, Fernandez-Valverde SL, Martinez Romero JC and Martinez-Romero E Systematic and Applied Microbiology | PDF | Journal
Find earlier publications on Pubmed and Google Scholar
If you are interested in joining the lab please email Selene at:
s [ d o t ] fernandez [ _ ] valverde [ A T ] unsw [ d o t ] edu [ d o t ] au
We are currently only accepting postdoctoral applications seeking support to apply for an independent fellowship.
We acknowledge the Bedegal people, the Traditional Owners of Country where the lab is currently located. We pay our respect to Aboriginal and Torres Strait Islander, Indigenous peoples of the Americas and First Nations people and cultures across the world.